In evaluating a patient with toxic psychosis, the clini cian should distinguish between a schizophreniform reaction with excessive sympathetic activity suggestive of amphetamine or co caine overdose and a sensory-distorted reaction more likely to accompany hallucinogen ingestion. Toxic psychosis due to exces sive anticholinergic intake is marked by abrupt onset, dilated pupils, and blurred vision. The basic principles of poison man agement should be followed, with close patient observation and conservative treatment.